Search results for "Research Support"

showing 10 items of 46 documents

Adjuvant chemotherapy and relative survival of patients with stage II colon cancer - A EURECCA international comparison between the Netherlands, Denm…

2016

BACKGROUND: The aim of the present EURECCA international comparison is to compare adjuvant chemotherapy and relative survival of patients with stage II colon cancer between European countries.METHODS: Population-based national cohort data (2004-2009) from the Netherlands (NL), Denmark (DK), Sweden (SE), England (ENG), Ireland (IE), and Belgium (BE) were obtained, as well as single-centre data from Lithuania. All surgically treated patients with stage II colon cancer were included. The proportion of patients receiving adjuvant chemotherapy was calculated and compared between countries. Besides, relative survival was calculated and compared between countries.RESULTS: Overall, 59,154 patients …

0301 basic medicineAdultMaleCancer Researchmedicine.medical_specialtyAdjuvant chemotherapyColorectal cancerPopulationDiseasePopulation-basedStage II03 medical and health sciences0302 clinical medicinePharmacotherapySDG 3 - Good Health and Well-beingInternal medicineAntineoplastic Combined Chemotherapy ProtocolsJournal ArticlemedicineHumansStage (cooking)educationInternational comparisonAgedGynecologyeducation.field_of_studyRelative survivalbusiness.industryResearch Support Non-U.S. Gov'tMiddle Agedmedicine.diseaseSurvival AnalysisColon cancerAdjuvant chemotherapyEurope030104 developmental biologyLogistic ModelsOncologyChemotherapy Adjuvant030220 oncology & carcinogenesisColonic NeoplasmsSurgeryFemalebusinessStage ii colon cancerEuropean journal of cancer (Oxford, England : 1990)
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IQSEC2-related encephalopathy in males and females: a comparative study including 37 novel patients.

2019

Variants in IQSEC2, escaping X inactivation, cause X-linked intellectual disability with frequent epilepsy in males and females. We aimed to investigate sex-specific differences.

0301 basic medicineMaleGénétique clinique[SDV]Life Sciences [q-bio]MedizinPhysiology030105 genetics & hereditySeizures/epidemiologyEpilepsyBrain Diseases/epidemiologyX-linked inheritanceIntellectual disabilityGuanine Nucleotide Exchange FactorsProtein IsoformsMissense mutationGenetics(clinical)10. No inequalityNon-U.S. Gov'tGenetics (clinical)X-linked recessive inheritanceComputingMilieux_MISCELLANEOUSBrain DiseasesSex CharacteristicsResearch Support Non-U.S. Gov'tBrainSciences bio-médicales et agricoles3. Good healthPedigreePhenotypeintellectual disabilityFemaleBrain/growth & developmentSex characteristicsGénétique moléculaireGuanine Nucleotide Exchange Factors/geneticsEncephalopathyResearch SupportX-inactivationArticle03 medical and health sciencesSeizuresProtein Isoforms/geneticsmedicineJournal ArticleIQSEC2HumansIntellectual Disability/epidemiology[SDV.GEN]Life Sciences [q-bio]/Geneticsbusiness.industryInfant NewbornisoformsCorrectionInfantmedicine.diseaseNewbornHuman genetics030104 developmental biologyMutationepilepsyHuman medicinebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

2016

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation o…

0301 basic medicineNephrologyGenetics and Molecular Biology (all)estimated glomerular filtration rateestimated glomerular filtration rate chronic kidney disease genetic determinantsGeneral Physics and AstronomyKidney developmentGenome-wide association studyBiochemistrySettore MED/14 - NEFROLOGIARenal InsufficiencyChronicGeneticsAGEN Consortiumddc:616education.field_of_studyKidneyStage renal-diseaseMultidisciplinaryGenome-wide associationCHARGe-Heart Failure GroupGene Expression Regulation; Genome-Wide Association Study; Genotype; Humans; Renal Insufficiency Chronic; Genetic Predisposition to Disease; Biochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)QChemistry (all)MetaanalysisGene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Renal Insufficiency Chronic/geneticsBiological sciencesSerum creatininemedicine.anatomical_structureEfficientRonyons -- FisiologiaHypertensionICBP ConsortiumTransmembrane transporter activitygenetic association loci kidney functionCARDIOGRAMHumanmedicine.medical_specialtyGenotypeSciencePopulationRenal functionECHOGen ConsortiumReplicationBiologyEnvironmentResearch SupportGeneral Biochemistry Genetics and Molecular BiologyN.I.H.genetic determinants03 medical and health sciencesPhysics and Astronomy (all)GENOME-WIDE ASSOCIATION ; FALSE DISCOVERY RATES ; STAGE RENAL-DISEASE ; SERUM CREATININE ; METAANALYSIS ; VARIANTS ; INDIVIDUALS ; POPULATION ; RISK ; HYPERTENSIONKidney functionResearch Support N.I.H. ExtramuralInternal medicineMD MultidisciplinarymedicineGeneticsJournal ArticleHumanseGFRcrea; eGFRcysGenetic Predisposition to Diseaseddc:610GenetikRenal Insufficiency ChronicMortalityeducationddc:613Biochemistry Genetics and Molecular Biology (all)urogenital systemIndividualsExtramuralGeneral Chemistryta3121medicine.diseaseR1030104 developmental biologyGene Expression RegulationBiochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)570 Life sciences; biologyGenèticachronic kidney diseaseKidney diseaseGenome-Wide Association StudyMeta-Analysis
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Guidelines for the use of flow cytometry and cell sorting in immunological studies

2017

The marriage between immunology and cytometry is one of the most stable and productive in the recent history of science. A rapid search in PubMed shows that, as of July 2017, using “flow cytometry immunology” as a search term yields more than 68 000 articles, the first of which, interestingly, is not about lymphocytes. It might be stated that, after a short engagement, the exchange of the wedding rings between immunology and cytometry officially occurred when the idea to link fluorochromes to monoclonal antibodies came about. After this, recognizing different types of cells became relatively easy and feasible not only by using a simple fluorescence microscope, but also by a complex and some…

0301 basic medicineT-LymphocytesCell SeparationT cell precursors0302 clinical medicineImmunophenotypingHuman lymphopoiesis[ SDV.IMM ] Life Sciences [q-bio]/ImmunologyImmunology and AllergyNon-U.S. Gov'tImmunologic Techniquemedicine.diagnostic_testResearch Support Non-U.S. Gov'tvirus diseaseshemic and immune systemsFalse Positive ReactionCell sortingFlow Cytometrynatural killer and innate lymphoid cells differentiation3. Good healthResearch Design[SDV.IMM]Life Sciences [q-bio]/ImmunologyHumanQuality Controlmedicine.drug_classImmunologyAnimals; Cell Proliferation; Cell Separation; DNA; False Positive Reactions; Flow Cytometry; Humans; Immunophenotyping; Quality Control; RNA; Research Design; Software; T-Lymphocytes; Guidelines as Topic; Immunologic Techniques; Immunology and Allergy; Immunologychemical and pharmacologic phenomenaGuidelines as TopicComputational biologyBiologyMonoclonal antibodyResearch SupportArticleFlow cytometryImmunophenotypingN.I.H.03 medical and health sciencesImmune systemImmunologic TechniqueResearch Support N.I.H. Extramuralmedicineearly lymphoid progenitorsJournal ArticleAnimalsHumansMass cytometryFalse Positive ReactionsImmunology and Allergy; Immunology; Flow cytometryIMUNOLOGIACell ProliferationAnimalExtramuralB cell ontogenyDNA030104 developmental biologyT-LymphocyteImmunologic TechniquesRNACytometrySoftware030215 immunologyEuropean Journal of Immunology
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Intraoperative transfusion practices in Europe

2016

PubMed: 26787795

AUSTRIAN BENCHMARKMaleBlood transfusionmedicine.medical_treatment610 Medizinanaemia anesthesia blood transfusion surgery transfusion trigger030204 cardiovascular system & hematologyGUIDELINESsurgeryCohort Studies0302 clinical medicine030202 anesthesiologyMedicine and Health SciencesMedicineProspective StudiesProspective cohort studyddc:610Research Support Non-U.S. Gov'tMiddle AgedHospitalsEuropeFemaleAllogeneic transfusionCohort studymedicine.medical_specialtyTransfusion rateObservational Studyanesthesiablood transfusionELECTIVE SURGERYClinical Practice03 medical and health sciencesJournal Articleanaemia ; anesthesia ; blood transfusion ; surgery ; transfusion triggerHumansBlood TransfusionElective surgeryCHLC ANSIntensive care medicineanaemiatransfusion triggerIntraoperative Carebusiness.industryPREOPERATIVE ANEMIAPATIENT BLOOD MANAGEMENTClinical trialAnesthesiology and Pain MedicineEmergency medicinebusinessPacked red blood cellsREQUIREMENTSBritish journal of anaesthesia
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First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3…

2016

Abstract Purpose: A first-in-human phase I study was conducted to characterize safety, efficacy, and pharmacokinetic (PK) and pharmacodynamic (PD) properties of lumretuzumab, a humanized and glycoengineered anti-HER3 monoclonal antibody, in patients with advanced cancer. Experimental Design: Twenty-five patients with histologically confirmed HER3-expressing tumors received lumretuzumab (100, 200, 400, 800, 1,600, and 2,000 mg) every two weeks (q2w) in 3+3 dose-escalation phase. In addition, 22 patients were enrolled into an extension cohort at 2,000 mg q2w. Results: There were no dose-limiting toxicities. Common adverse events (any grade) included diarrhea (22 patients, 46.8%), fatigue (21 …

AdultMale0301 basic medicineCancer Researchmedicine.medical_specialtyPathologyMaximum Tolerated DoseReceptor ErbB-3CmaxAntibodies Monoclonal HumanizedResearch SupportGastroenterologyClinical Trial Phase I03 medical and health sciencesPhase I0302 clinical medicinePharmacokineticsInternal medicineJournal ArticlemedicineHumansNon-U.S. Gov'tAdverse effectAgedAnalgesicsbusiness.industryResearch Support Non-U.S. Gov'tCancerMiddle AgedLumretuzumabmedicine.diseaseClinical TrialMulticenter StudyTreatment Outcome030104 developmental biologyOncology030220 oncology & carcinogenesisPharmacodynamicsMonoclonalFemaleColorectal NeoplasmsbusinessEx vivo
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Brain Function and Upper Limb Outcome in Stroke: A Cross-Sectional fMRI Study

2015

Objective The nature of changes in brain activation related to good recovery of arm function after stroke is still unclear. While the notion that this is a reflection of neuronal plasticity has gained much support, confounding by compensatory strategies cannot be ruled out. We address this issue by comparing brain activity in recovered patients 6 months after stroke with healthy controls. Methods We included 20 patients with upper limb paresis due to ischemic stroke and 15 controls. We measured brain activation during a finger flexion-extension task with functional MRI, and the relationship between brain activation and hand function. Patients exhibited various levels of recovery, but all we…

AdultMalemedicine.medical_specialtyBrain activity and meditationlcsh:MedicineElectromyographyResearch SupportFunctional LateralityBrain IschemiaUpper ExtremityBrain ischemiaPhysical medicine and rehabilitationSDG 3 - Good Health and Well-beingFunctional neuroimagingNeuroplasticityJournal ArticlemedicineHumanslcsh:ScienceNon-U.S. Gov'tStrokeMotor skillAgedNeuronal PlasticityMultidisciplinarymedicine.diagnostic_testbusiness.industryFunctional NeuroimagingResearch Support Non-U.S. Gov'tlcsh:RBrainRecovery of FunctionMiddle Agedmedicine.diseaseMagnetic Resonance ImagingStrokeMotor SkillsPhysical therapy/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beinglcsh:QFemaleFunctional magnetic resonance imagingbusinessResearch ArticlePLOS ONE
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Oxygen binding properties of non-mammalian nerve globins

2006

Oxygen-binding globins occur in the nervous systems of both invertebrates and vertebrates. While the function of invertebrate nerve haemoglobins as oxygen stores that extend neural excitability under hypoxia has been convincingly demonstrated, the physiological role of vertebrate neuroglobins is less well understood. Here we provide a detailed analysis of the oxygenation characteristics of nerve haemoglobins from an annelid (Aphrodite aculeata), a nemertean (Cerebratulus lacteus) and a bivalve (Spisula solidissima) and of neuroglobin from zebrafish (Danio rerio). The functional differences have been related to haem coordination: the haem is pentacoordinate (as in human haemoglobin and myogl…

AnnelidaDanioNeuroglobinNerve Tissue ProteinsCooperativityBiochemistryHemoglobinschemistry.chemical_compoundJournal ArticleAnimalsGlobinNerve TissueMolecular BiologyConserved SequenceZebrafishAnnelidbiologyResearch Support Non-U.S. Gov'tTemperatureHexacoordinateCell BiologyHydrogen-Ion Concentrationbiology.organism_classificationGlobinsOxygenMyoglobinchemistryBiochemistryNeuroglobinOxygen binding
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EVpedia: a community web portal for extracellular vesicles research

2014

Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more tha…

Biomedical ResearchDatabases FactualComputer scienceBioactive moleculesMedizinBioinformaticsBiochemistryMathematical SciencesUser-Computer InterfaceNon-U.S. Gov'tdatabasecomputer.programming_languagePLASMAMICROPARTICLESResearch Support Non-U.S. Gov'tbioinformaticsBiological SciencesOriginal PapersCANCERComputer Science ApplicationsIdentification (information)Cell and molecular biologyComputational MathematicsComputational Theory and MathematicsPROTEOMIC ANALYSISMEMBRANE-VESICLESEXPRESSIONStatistics and ProbabilityPROSTASOMESJavaBioinformaticsexosomesResearch SupportExtracellular vesiclesWorld Wide WebDatabasesDELIVERYInformation and Computing SciencesJournal ArticleHumansMembrane vesicleMolecular BiologyFactualEXOSOMESComputational BiologyCELLSDatabase Management SystemsExtracellular SpacecomputerSoftware
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Predatory journals enter biomedical databases through public funding

2020

Predatory publishing is an international, cross disciplinary threat to the integrity of the scientific system • A worrying number of articles published in predatory journals are indexed in biomedical databases such as PubMed, the free access biomedical database maintained by the National Library of Medicine • Public funding, under open access policies, seems to be the mechanism by which articles are displayed in PubMed. • Providing guidance to publicly funded authors on how to publish their work in legitimate open-access venues will likely stop the wasteful use of public money to cover the fees of predatory journals.

Biomedical Researchbusiness.industryfundingGeneral Medicine030204 cardiovascular system & hematologyPublic relationsPublic Expendituresopen acce03 medical and health sciences0302 clinical medicinePredatory publishingWork (electrical)Open Access PublishingResearch Support as TopicPolitical scienceHumanspredatory publishing030212 general & internal medicinePeriodicals as TopicbusinessGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)Public fundingPublication
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